For all cities with a population greater than five hundred thousand, Karshi is closest to Dushanbe and farthest from Santiago. The closest foreign city is Dushanbe and the farthest domestic city is Tashkent. See below for the top 5 closest and farthest cities (domestically, internationally and by continent) and to see which cities, if any, Karshi is the closest and farthest to. Filter to include all cities over 100k, 500k or 1 million in population.