For all cities with a population greater than five hundred thousand, Samarkand is closest to Dushanbe and farthest from Santiago. The closest foreign city is Dushanbe and the farthest domestic city is Tashkent. See below for the top 5 closest and farthest cities (domestically, internationally and by continent) and to see which cities, if any, Samarkand is the closest and farthest to. Filter to include all cities over 100k, 500k or 1 million in population.