For all cities with a population greater than five hundred thousand, Santa Elena is closest to Guayaquil and farthest from Medan. The closest foreign city is Chiclayo and the farthest domestic city is Quito. See below for the top 5 closest and farthest cities (domestically, internationally and by continent) and to see which cities, if any, Santa Elena is the closest and farthest to. Filter to include all cities over 100k, 500k or 1 million in population.