For all cities with a population greater than five hundred thousand, Santa Cruz is closest to Cochabamba and farthest from Valenzuela. The closest foreign city is Salta and the farthest domestic city is El Alto. See below for the top 5 closest and farthest cities (domestically, internationally and by continent) and to see which cities, if any, Santa Cruz is the closest and farthest to. Filter to include all cities over 100k, 500k or 1 million in population.